Irritable Male Syndrome

Irritability & Mood Swings in Men


Aging can be a difficult process for men, but it becomes harder due to mood swings caused by low levels of testosterone and HGH. Studies have shown that being irritable is usually a sign of hormone imbalance, and men over age 40 are more frequently affected.

Irritable male syndrome (IMS) is a diagnosis that describes men with severe mood swings. The lower levels of testosterone or HGH result in higher stress levels, which in turn cause inflated cortisol levels. You may be suffering from IMS if you find yourself having some of these symptoms:

  • Anger at self or others
  • Impatience
  • Sarcastic or constantly pessimistic
  • Anxious often or constantly
  • Tension or not being able to relax
  • Hostility or overreacting
  • Argumentative
  • Unloving
  • Easily frustrated
  • Withdrawn
  • Demanding
  • Defensive
  • Sad
  • Dissatisfied

High estrogen levels also induce IMS, as it means there are lower levels of testosterone or HGH. Both stress (higher cortisol levels) and weight gain are associated with low testosterone and low HGH. Men with higher cortisol or estrogen levels and low testosterone or HGH levels are prime candidates for IMS.


At the Oklahoma Men’s Clinic, we take a holistic approach when it comes to treatment. We begin by having our specialists and staff perform in-depth testing and diagnostics to understand if there are any underlying issues with your problem. From the results of these tests, we will recommend the safest and most effective treatment options. Two of our treatment options are the vitality blended testosterone hormone therapy and our Restore low-level HGH therapy, both of which can increase the levels of testosterone or HGH in your body and help with IMS symptoms. Our staff will work closely with you to make sure your needs are being met, and answer any questions or concerns you may have. Our goals are your goals, and we want to get you back to the man you used to be.