Drugs That May Cause Impotence


Limitations Caused by Medications & Recreational Drugs

Research has shown that the ability to achieve and sustain an erection can be limited by prescribed medicines and recreational drugs. This is different for every individual, but is an important factor in looking at sexual health. Quite a few medications and recreational drugs can impact sexual performance and arousal. If you think your medications may be affecting your sexual prowess, it’s important to get a medical professional to check. At the Oklahoma Men’s Clinic, we specialize in helping men to achieve their peak sexual health. Our physicians can examine your current medications and see if there is an issue. The Oklahoma Men’s Clinic physicians will also thoroughly examine your medical history to ensure you are healthy enough to have sex, go over any surgeries or conditions you have or have had, perform an ultrasound to confirm you have proper blood flow, do a complete BMI (body mass index) test to check for obesity and weight issues that may be affecting your ability to become erect, and finally do comprehensive blood work so we can render the best-educated opinion of what will work best for you.

We believe in a holistic approach when it comes to effective treatment, which is why we look for any underlying issues within our testing. Our treatments have helped hundreds of men, and have been proven effective through various research studies. Whether it’s our new prolific therapy (which requires little or no medication), bypass sublingual therapy, or TRI-MED therapy, our staff will advise you on all of your options. We will work closely with you to make sure you get the treatment and help you need and deserve. We know that this can be a difficult process, which is why we provide an environment of confidentiality and safety, so you can easily get help.

Antidepressants and psychological drugs:

Antidepressants have a tendency to reduce sensitivity of the penis. Low sensitivity can reduce stimulation, which can result in not being able to ejaculate. Some drugs that may produce this side effect include: Celexa (citalopram), Zoloft (sertraline), Paxil (paroxetine), and Lexapro (escitalopram).

Antihistamines, both prescription and over the counter:

Although not all men experience negative sexual side effects when taking these medications, some antihistamines are believed to limit some sexual functions. Some examples are: Tagamet, Dramamine, Benadryl, Axid, and Zantac.

Blood pressure and diuretic medicines:

Because these medications contain beta blockers or thiazides, they may inhibit intimacy. Some examples are: Prinivil, Zestril, and lisinopril.

PD (Parkinson’s disease) medicines:

These medications may affect sexual function: Cogentin, Parlodel, Kemadrin, and Duopa.

Chemotherapy medications:

These medications may cause loss of sexual function: Abraxane, Adriamycin, Paraplatin, Cytoxan, Cerubidine, DaunoXome, and Doxil.


The use or abuse of the following medications may impact the ability to be intimate: codeine, Demerol, methadone, morphine, oxycodone, and Oxycontin.

Recreational drugs:

The following recreational drugs have been shown to negatively affect sexual function: alcohol, amphetamines, cocaine, marijuana, heroin, and nicotine.